Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion
Neutrophil, or polymorphonuclear leukocyte (PMN), migration across intestinal epithelial barriers, such as occurs in many disease states, appears to result in modifications of epithelial barrier and ion transport functions (Nash, S., J. Stafford, and J. L. Madara. 1987. J. Clin. Invest. 80:1104-1113; Madara, J. L., C. A. Parkos, S. P. Colgan, R. J. MacLeod, S. Nash, J. B. Matthews, C. Delp, and W. I. Lencer. 1992. J. Clin. Invest. 89:1938-1944). Here we investigate the effects of epithelial exposure to IFN-gamma on PMN migration across cultured monolayers of the human intestinal epithelial cell line T84. Transepithelial migration of PMN was initially assessed in the apical-to-basolateral direction, since previous studies indicate general qualitative similarities between PMN migration in the apical-to-basolateral and in the basolateral-to-apical directions. In the apical-to-basolateral direction, epithelial exposure to IFN-gamma markedly upregulated transepithelial migration of PMN in a dose- and time-dependent fashion as measured by both electrical and myeloperoxidase assays. This IFN-gamma-elicited effect on transmigration was specifically due to a IFN-gamma effect on epithelial cells and was not secondary to IFN-gamma effects on epithelial tight junction permeability. Moreover, this IFN-gamma effect was dependent on epithelial protein synthesis, and involved a pathway in which CD11b/18, but not ICAM-1 or CD11a/18, appeared to play a crucial role in PMN-epithelial adhesion. IFN-gamma also substantially modified PMN transepithelial migration in the natural, basolateral-to-apical direction. The IFN-gamma effect on naturally directed transmigration was also specifically due to an IFN-gamma effect on epithelial cells, showed comparable time and dose dependency to that of oppositely directed migration, was CD11b/18 dependent, and required epithelial protein synthesis. Additionally, however, important qualitative differences existed in how IFN-gamma affected transmigration in the two directions. In contrast to apical-to-basolateral directed migration, IFN-gamma markedly downregulated transepithelial migration of PMN in the natural direction. This downregulation of PMN migration in the natural direction, however, was not due to failure of PMN to move across filters and into monolayers. Indeed, IFN-gamma exposure to epithelia increased the number of PMN which had moved into the basolateral space of the epithelium in naturally directed transmigration. These results represent the first detailed report of influences on PMN transepithelial migration by a cytokine, define conditions under which a qualitative difference in PMN transepithelial migration exists, and suggest that migration of PMN across epithelia in the natural direction may involve multiple steps which can be differentially regulated by cytokines.(ABSTRACT TRUNCATED AT 400 WORDS)
Naruto: 15 Things You Didn’t Know About Madara
Madara Uchiha plays a prominent role in the Naruto franchise as the foremost antagonist. His traits throughout the series are that of someone who has a giant ego, causing him clash with Hashirama Senju’s reasoning and sensibility repeatedly.
However, it wasn’t just Hashirama whom he clashed with-- his manipulative and egocentric personality would eventually lead to him disagreeing with his own clan members, especially after he co-founded the village of Konohagakure (the Village Hidden in Leaves).
Despite being a prodigy, Madara didn’t start out his life at odds with everyone around him. He was born during a time filled with war and it was all he had ever known. Death was a way of life, and power kept you alive longer than those around you. The power that Madara would draw on for strength to deal with the world he was born into would eventually take over any innocence that was once a part of him.
Madara is known for having some of the best evil quotes out of all the villains from Naruto. These famous lines would permanently etch Madara into the Naruto universe as one of the best evil characters in the series. Quotes such as “Man seeks peace, yet at the same time yearning for war. Thinking of peace whilst spilling blood is something only human could do. They’re two sides of the same coin,”sum up who Madara really is.
From dreams of peace as a child to the war of all wars, here are the 15 Things You Didn’t Know About Naruto's Madara.
15 He Was The Master Of 10 Nature Transformations
There are five fundamental nature transformations in Naruto — fire, wind, lightning, earth, and fire. Combining two or more of these transformations together at the same time results in new elemental properties and transformations that wouldn’t exist on their own. There is also Yin Release, which is based on spiritual energy, and Yang Release, which is based on vitality and physical energy.
Madara mastered all five standard nature transformations, along with Yin Release, Yang Release, Yin-Yang, Storm Release, and Wood Release. He spent years mastering the Wood Release, using the DNA he stole from Hashirama Senju.
Madara was a shinobi prodigy and one of the most talented fighters in history. Of the Uchiha Clan, he is recognized as one of its strongest members. He was also born with powerful chakra, described as evil, and could tap into it while fighting for up to 24 hours straight.
14 He Used Demonic Statue of the Outer Path As A Life Source
The Demonic Statue of the Outer Path (外道魔像) is the hollowed body of the Ten-Tailed Beast. It only answers those who possess the Rinnegan. Madara used this idol to keep him alive, making him the only person in Naruto to use the Demonic Statue of the Outer Path in this manner.
Nagato tried to tap into the statue like Madara did, but it nearly killed him. This was most likely because Madara tapped into the flower and not the idol itself.
Madara had three stems protruding from his back that entered into the flower stem that the statue sits on. The flower acted as a base and fed off the statue. He used it to not only extend his life so he could complete his training with Obito, but also as a vessel to harvest Hashirama's DNA while also creating plant-like humanoids from it.
13 He Was Technically The First Hokage
The Senju Clan and the Uchiha Clan were natural enemies of one another. Madara became the leader of Uchiha, while Hashirama led the Senju Clan.
After being defeated by Hashirama several times, Madara finally accepted his offer for a truce. They created a village that would be a symbol of this peace that Madara named Konohagakure, the Village Hidden. Hashirama also appointed Madara as the First Hokage of Konohagakure (Lord of Konoha).
Tobirama, however, was against Madara being Hokage, so he proposed that the First Hokage be decided by a vote. Hashirama, being the stronger of the two and more popular amongst both clans, was voted in as First Hokage.
Incidentally, this would be the only time that a vote was taken after a recommendation was given. It should also be noted that all Seven Hokage in Naruto, can be traced back to Hashirama Senju in some manner.
12 He Was First Full Blood Human Uchiha To Awaken Rinnegan
The Rinnegan, or Saṃsāra Eye, was first manifested by Hagoromo Ōtsutsuki. His was a Rinnegan that was a kekkei mōra, which is classified as a jutsu unique to Kaguya Ōtsutsuki and her direct bloodline.
Madara was able to obtain the Rinnegan only after infusing himself with Hashirama's DNA. This would be the first time in history that a Rinnegan would appear outside of Kaguya Ōtsutsuki’s direct blood line.
The only downfall to Madara’s Rinnegan was that he didn’t have full access to the original’s abilities. Naturally the Rinnegan can be transplanted into another’s eyes, like any dōjutsu.
Madara implanted both of his eyes in Nagato when he was young without his knowledge, which he took full advantage of because of his Senju lineage. After Nagato's death, Obito Uchiha took the Rinnegan.
11 He Didn’t Create The Zetsus
Madara used the Demonic Statue of the Outer Path to harvest Hashirama's DNA and create humanoids from it, bringing the Zetsu to life. Madara assumed that these Zetsus were created by him, but it would later be revealed that all the Zetsus were actually humans who had been merged with the God Tree.
The Zetsus were originally victims of Kaguya Ōtsutsuki's Infinite Tsukuyomi, who were tethered to the God Tree over the course of years and were stored within the Demonic Statue of the Outer Path.
Black Zetsu would pull White Zetsu and other victims from the husk of the statue after Madara had summoned and cultivated it with Hashirama Senju's DNA. The naivety of Madara thinking that he had created the Zetsus would lead to his downfall after his resurrection.
10 He Was The Only Character To Detect Shadow Clones
Madara was unique in the Naruto series since he awakened his Sharingan while still a child, with one tomoe in both eyes. By the time he was approaching adulthood, Madara could use the Sharingan better than any of the other members in the Uchiha clan.
In the Naruto series as a whole, he would be the only individual who could detect shadow or wood clones (specifically when used by Naruto and Hashirama).
Madara could place targets under genjutsu and paralyze them with the briefest of eye contact. His Sharingan even had the ability to trap the Nine-Tails Beast. Madara showed his full power of it when he programed one of his eyes to activate Izanagi after his death, allowing him to alter reality and resurrect himself.
9 He Loved To Fight More Than Anything Else
Madara's favorite phrase is “armor-sleeved single hit” (鎧袖一触). In other words, he loved to destroy his opponent with a single killing blow. Killing gave Madara joy and purpose.
He loved the taste of his own blood, along with the sights and sounds of the battlefield. You could almost say that fighting was his addiction— it satisfied him, but left him craving more.
What Madara didn’t expect and hated about being resurrected was that he couldn’t fully experience the thrill of battle. Despite being so in tune with the sensory part of fighting, he always remained disciplined.
You wouldn’t know he was upset about not fully experiencing battle after reincarnation because he wouldn’t show it. Madara was all about obtaining victory at any cost and this meant not letting failed plans or obstacles get in his way.
8 His Dominant Element Was Wind, Not Fire
Madara is one of the strongest members of the Uchiha Clan, which would lead you to think that fire was his element of choice. However, in truth, Madara hated fire, and felt that wind fit his personality and style more appropriately.
This doesn’t mean that he never used fire, though. In fact, he would often combine fire and wind together. Madara did whatever he needed to in order to be victorious even if that meant using an element he disliked, such as fire.
In the anime, Madara often produced giant walls of flame that took several water users to put out. He would also combine wind to create a moving fire wall or project dragon-shaped fireballs at his opponents. It should also be noted that Madara wasn’t afraid to use the other elements, as he often combined them as whenever he needed.
7 He’s Not Listed As A Senjutsu User Despite His Use Of The Six Paths
Despite popular claims, Madara is technically not listed as a user of senjutsu in the fourth Naruto databook. Most assume that he is because he’s a user of the Six Paths Senjutsu.
He’s also known for using sage art Yin Release Lightning Dispatch, along with Storm Release Light Fang. For the Naruto manga lovers, both were depicted in white (even in the color manga). While in the anime, Yin Release Lightning Dispatch is shown in purple.
Perhaps Madara isn’t listed as a senjutsu user because he stole the ability of being able to use the Six Paths Senjutsu from Hashirama's DNA. Unfortuantely, the fourth data book doesn’t go into any detail as to why Madara is listed the way he is.
Madara is most often recognized with using the Six Paths Ten-Tails Coffin Seal technique.
6 He Wasn’t Totally Evil
Though he loved the taste of his own blood and its noted several times that his chakra itself can be seen as evil, Madara himself wasn’t a bad person — he just let circumstances in life lead him down an evil path.
A few notable good qualities about Madara that many fans might not know about would be that he viewed men and women equally. He never looked down on a woman in battle and would fight them as he would a man. In his mind, the only difference between the two was that a woman could give birth, which didn't cause any differences on the battlefield.
Madara was also frugal with his money. Power and money usually go together, but not for Madara. He often enjoyed items that were cheaper and was never known to buy anything extravagant.
5 Only Naruto Had More Jutsu Techniques Than Madara
Madara was more than competent with a large variety of ninjutsu styles, making him a lethal combatant to go up against. He was known for using juinjutsu to restrict his opponents actions, hide within the surface of a battle field, fake his death using a Shadow Clone, and even levitate.
With 52 Jutsu techniques, Madara led the pack second only to Naruto, who had a whopping 81 recorded Jutsu techniques.
Madara also loved to use weapons while battling. His favorite was his gunbai, a non-folding fan which is carved from a spirit tree. His gunbai had been passed down between Uchiha warriors for generations.
Madara would use it to redirect and shield attacks, also occasionally wielding it like a mace. This specific gunbai could convert chakra into wind nature transformation.
4 His Love For Izuna Was Stronger Than Itachi’s For Sasuke
Izuna was not Madara’s only sibling. There were three other brothers who all died at a very young age at the hands of Senju Clansman. However, the deaths of their siblings brought Madara and Izuna closer together, forming a bond that would last past Izuna’s lifetime. After Izuna awakened his Mangekyō Sharingan, the two brothers would become the heads of the Uchiha Clan.
Izuna later became mortally wounded by Tobirama (Hashirama’s brother) in a battle. Hashirama then asked Madara if peace could finally be an option between the two clans.
Madara considered the offer until Izuna told him not to listen to Hashirama’s lies. This caused Madara to retreat with Izuna, who would later die and give Madara his eyes. This last act of love by Izuna allowed Madara to gain the Eternal Mangekyō Sharingan.
3 He Only Did What He Wanted To Do
Despite Uchiha clansman voicing their opinions on wanting peace with the Senju Clan, Madara ignored them as their leader and followed through on the path that he felt was best for the Uchiha Clan.
Following his defection from Konoha, his resolve to accomplish his tasks took priority over everything around him. Madara would resort to manipulation and lying to get what he wanted no matter the cost.
Madara would even place contingency plans into every move he made so that his intentions would always come to fruition despite the actions taken by others to stop him.
Power would become something that Madara enjoyed and coveted. Even wasting his power on what he considered insignificant battles would upset him, showing how he put his abilities on a pedestal above others.
2 He Lived To Be 120 Before First Official Death
Madara’s long life was extended by the Demonic Statue of the Outer Path, but his reasons for living longer were what allowed him to achieve the age of 120 before dying. Madara knew that he had obtained the power he wanted to late in life, with his weak and old body unable to perform the tasks he wanted to achieve.
His contingency plan was to extend his life as long as possible so he could train Obito and form him (with mind-controling devices) into the perfect and obedient soilder, known to Naruto fans as Tobi.
He would also infuse part of his will into Black Zetsu, thinking that it was a creation of his and his Rinnegan to Nagato so that he could later be revived. This would allow Black Zetsu to watch over Tobi and Negato, making sure things went according to plan — which they didn’t.
If Madara had been able to accomplished what he wanted prior to his death, who knows how old he would have lived to be.
1 He Admired And Hated Hashirama Senju
Despite all the animosity that would take place between Hashirama and Madara, the two shared similar ideals when they were younger. The two boys grew up in an era of permanent war, in which they even had to keep their names a secret out of fear of being attacked.
Madara and Hashirama would become childhood friends because they both felt that the slaughter of children forced to fight on the battlefield was senseless.
Before Madara’s second death, he would set things straight with Hashirama. He told him that, while his dream for peace had died, Hashirama’s dream would live on. Hashirama would then tell Madara that, despite everything that they’ve been through, he still considered Madara as a friend. Madara agreed to this with his final breath before he passed on.
Can you think of any other interesting facts about Naruto's main villain? Let us know in the comments!
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Daniel is a gamer and freelance writer who lives in the Orlando area. His first loves are Star Wars, anime, gaming, movies, and food. You can find Daniel on Twitter @dannyspacecoast or playing Starfighter Assault on Battlefront II. "May the Schwartz be with You"
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the first symptom of a cold is usually a sore throat. this is generally followed by sneezing or a blocked, sore or runny nose. usually, 1 in 3 people with a cold will get a cough and feel unwell.
colds are caused by viruses. antibiotics cannot treat viruses. instead, drink plenty of liquids to replace those lost from sweating and runny noses. get lots of rest and eat healthily. do not ask your gp for antibiotics for a cold.
you will usually feel worse during the first 2 to 3 days before gradually starting to improve. your symptoms will usually last about a week.
cold and flu symptoms are similar but flu tends to be more severe.
- appears gradually
- affects mainly your nose and throat
- makes you feel unwell but you're ok to carry on as normal - for example, go to work
- appears quickly within a few hours
- affects more than just your nose and throat
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cold symptoms can include:
- blocked or runny nose
- sore throat
- muscle aches
- a raised temperature
- pressure in your ears and face
- loss of taste and smell
the symptoms are the same in adults and children. sometimes, symptoms last longer in children.
causes of colds
colds are caused by viruses. they can easily spread to other people. you're infectious until all your symptoms have gone. this usually takes about a week.
colds are spread by germs from coughs and sneezes which can live on hands and surfaces for 24 hours.
to reduce the risk of spreading a cold you should:
- wash your hands often with warm water and soap
- cough into your elbow to stop germs getting on to your hands and spreading to other people
- use tissues to trap germs when you cough or sneeze
- bin used tissues as quickly as possible
how to prevent catching a cold
the best ways to avoid catching a cold are:
- washing your hands with warm water and soap, especially before eating
- not sharing towels or household items, like cups, with someone who has a cold
- not touching your eyes or nose. you can infect your body if you've come into contact with the virus.
- staying fit and healthy
Fictional character from Naruto
Madara Uchiha (Japanese: うちは マダラ, Hepburn: Uchiha Madara) is a fictional manga and anime character in the Naruto series created by Masashi Kishimoto. He appears for the first time in "Part II" of the manga and the Shippuden anime adaptation, as a major villain. He, along with its first HokageHashirama Senju, is one of the co-founders of Konohagakure (Japanese: 木ノ葉隠れの里, Hepburn: Konohagakure no Sato) village from the ninja world. Their power conflict over how to run the village, as well as the long-term feud between clans, leads to Madara's death. However, it is revealed later that Madara had used a man named Obito Uchiha as his agent. He transplants his Rinnegan (輪廻眼, lit. "Saṃsāra Eye") eye power into a child named Nagato, the leader of the terrorist organization Akatsuki, to be preserved for his eventual revival years later. During most of the series, Obito uses Madara's name until a criminal named Kabuto Yakushi reanimates the real Madara who becomes one of the primary antagonists alongside Obito Uchiha during the Fourth Great Shinobi World War storyline. Madara has appeared in several pieces of Naruto media, including a Boruto feature film. Many Naruto video games have featured him as a playable character.
Kishimoto created the character to provide a strong villain in the series' final arc who would face the series' protagonist, Naruto Uzumaki. This confrontation would be different from that with previous enemies and result in more of a focus on fight scenes. Merchandise has been released in Madara's likeness, including keychains, plush dolls, and figurines. In the Japanese anime, Naoya Uchida voices Madara, while Go Inoue voices him as a child. In the English version, Neil Kaplan provides Madara's voice with Xander Mobus voicing him as a child. Critics have commented on his role as an antagonist in the series; some have placed him on top all-time anime villains lists, while others have criticized his effectiveness. Nevertheless, Madara's background was well-received for how integral his story is to the series' scenario.
Creation and design
Madara originated from Masashi Kishimoto's desire to elaborate on the ending to the manga series Naruto. Once the series began its second part, simply referred to as "Part II" in the manga and Shippuden in the anime, Kishimoto felt the need to create a story arc that would emphasize the tragedy of wars, leading to the final arc which would include a war. According to Kishimoto, Naruto and his group were weak as children in the first part and he wanted to make them stronger in the second part. This is the reason he introduced the Akatsuki (and later on Madara) as their enemies. In an interview, Kishimoto asserted that making the villains "flamboyant" was one of the "guiding principles" he followed. It was his desire to create villains with "powerful auras". Madara appears late in the manga, as one of the masterminds leading to the fourth shinobi world war, in the final arc. Nevertheless, he wanted to make him an engaging antagonist who would clash with Sasuke Uchiha and the Tailed Beast known as the Ten Tails to give the storyline a proper conclusion.
According to Kishimoto, Madara is not just like any other character introduced in the series. He created Madara as a character with no weaknesses. As one of the antagonists in the story, Kishimoto designed Madara as the antithesis to the protagonists' values, a perfect anti-hero. Kishimoto also said Naruto always defeated his enemies without intending to kill them by settling disputes with words since his battle with Nagato. Naruto truly forgave his enemy instead of having kill them, a concept Kishimoto liked but which no other shonen manga truly followed. Kishimoto found the idea of the two characters interacting and settling their differences more interesting and challenging, rather than killing them. So from the Nagato battle onwards, he decided to introduce the resurrected Madara to have someone to beat. According to Kishimoto, this was one of the reasons why he introduced Edo-Madara into the storyline. But he confessed this was complicated at first. It ended up with confusion about the difference between the two characters.
Japanese voice actor Naoya Uchida enjoyed voicing Madara's character, most notably in his final recording where he sent regards to fellow actor Kazuhiko Inoue (Kakashi Hatake) and Wataru Takagi (Obito Uchiha).Neil Kaplan first voiced Madara in the video game Naruto Shippuden: Ultimate Ninja Storm 3. Because CyberConnect2's fighting game's storyline preceded the television series' plot, he was asked by their staff to read the series' manga to get an idea of the character. Kaplan said this made it difficult for him to voice Madara for the first time.
Madara is mentioned in the second part of the manga Naruto but does not appear in most of the series except the war arc. During his childhood, he met a child named Hashirama, but amidst the conflicts of their respective clans resulting in war, their friendship ends. After failing at several attempts to kill or defeat his rival, Madara became friends with him and accepted his treaty offering peace between the two clans. The Uchiha, Senju and all of their affiliated clans came together to form a village, which Madara named Konohagakure. Madara took a merciless approach and did not like Hashirama's compassionate methods. After the death of his brother, Izuna, Madara became cynical and vengeful and held a grudge against the Senju Clan for slaughtering his brothers in the War. After his defection from Konoha, he believed there is no real peace. Losing all of his family and conflicted over his own clanmates, he decided to free the world from its pains, by casting Infinite Tsukuyomi (無限月読, Mugen Tsukuyomi) upon the whole world so that there would be no war and no death. Madara is believed to have been killed by Hashirama's hand, but he survives and goes into hiding. He awakens the legendary Eye Technique Rinnegan using Hashirama's DNA. Before dying, Madara takes Obito as his agent and transplants his Rinnegan into Nagato to be preserved for his eventual revival years later. After Madara's death, his greatest lasting influence was on Obito, one of his descendants, who used Madara's knowledge to strongly influence and control the Akatsuki behind the scenes, and pretended to be Madara for much of the manga's story. When Obito moves into the final stages of Madara's goal by initiating the Fourth Shinobi World War, Kabuto Yakushi forms an alliance with him, eventually reviving Madara's reanimated corpse.
By nightfall, Madara releases himself from Kabuto's contract and rebounds his soul to the modified immortal body enabling him to act on his own will. Madara decides to reclaim the Nine-Tails creature sealed within Naruto and defeats the Kages, only to reunite with Obito while he is engaged in combat with the shinobis. Madara fully resurrects himself by sacrificing the defeated Obito, ordering Black Zetsu to take control over Obito's body and perform the Samsara of Heavenly Life Technique. Restored to life, Madara unlocks his full potential and manages to break free of his restraints. Defeating his enemies, Madara goes after the Tailed beasts to revive Ten-Tails. Madara is then confronted by Might Guy, Minato Namikaze, Gaara and Rock Lee who each use all of their forces to kill him but fail. Before killing most of his enemies, Madara is confronted by the healed Naruto Uzumaki and Sasuke Uchiha who overwhelm him. Madara is forced to escape and regain Obito's Rinnegan. Upon returning to the field, Madara succeeds in casting the Infinite Tsukuyomi. The entire world becomes trapped in the dream. Sasuke manages to save Naruto, Kakashi, and Sakura from this Illusionary Technique, and Black Zetsu stabs Madara, gaining control over his body. Black Zetsu reveals that it was never Madara's will but Kaguya's Madara swells in size, Kaguya taking his place. Naruto, Sasuke, Sakura and Kakashi manage to seal Kaguya, who reverts into ten tails before being sealed spitting out Madara. Eventually, Madara dies because of the toll of both the tailed beasts and Demonic Statue removed from his body. In his final moments, Madara finds real peace within the dreams of Hashirama, stating that his dream for peace has died while Hashirama's dream for peace lives on and will always keep living on as it is the better of the two. Before dying, he acknowledges the friendship of Hashirama and agrees with him when he said, that they are still friends despite everything.
In other media
Madara appears in the original video animation Hashirama Senju vs. Madara Uchiha (2012); Obito narrates the origin of Konoha. In the beginning, ninja fought for their own clans. The most powerful among them are two clans: the Senju led by Hashirama, and the Uchiha led by Madara. This was distributed as part of the Naruto Shippuden: Ultimate Ninja Storm Generations video game for the PlayStation 3 and Xbox 360. Although Obito impersonates Madara, the character made his debut in a video game in Naruto Shippuden: Ultimate Ninja Storm 3. His Ten-Tailed Beast Host incarnation also appears in Naruto Shippuden: Ultimate Ninja Storm 4. In The Last: Naruto the Movie (2014), Madara appears for a brief moment to be seen fighting with Hashirama They are depicted as the reincarnation of Indra and Ashura, which gradually leads to the final battle between Sasuke and Naruto. Madara also appears in the iOS and Android mobile game Naruto Shippuden: Ultimate Ninja Blazing. Apart from the Naruto games, the character also appears in the crossover fighting games J-Stars Victory VS and Jump Force as downloadable content.
Several merchandise items based on Madara have been released, including key chains, action figures, and many more items.
Madara has been a popular character from the Naruto series. He is featured in most of the powerful anime character lists from different anime reviewers. Comic Book Resources listed him third on their list of "25 Most Powerful Anime Villains", praising his strength. Comic Book Resources also featured him on their list of "10 Anime Characters Who Got Stronger After Coming Back From The Dead" and gave him the ninth spot.Comic Vine rated him 34th on their "Top 100 Anime Villains" list. TheGamer, a news website focused on video game journalism, however, ranks him at fifth on their list titled "Final Form: The 25 Strongest Anime Villains Ever, Officially Ranked". Madara is also sixth on Screen Rant's list titled "20 Most Powerful Naruto Characters, Ranked"; author Bobby Anhalt writes that, "Madara Uchiha is a force to be taken seriously." UK Anime Network felt Madara's introduction was one of the franchise's strongest developments not only for the direction he took fight scenes but because of his effect on the main storyline. His next battle against the five Kages, the leaders of each ninja village, also earned acclaim for its execution, making the final story arc more appealing. UK Anime's reviewer also liked Naruto's fight against Obito which began in the same narrative. The Fandom Post praised this fight, noted how each Kage tries to defeat Madara on their own, but he is overwhelming does not care about his rivals.Siliconera enjoyed Madara's moves from the video game Storm 4 based on the his Susanoo technique which was appealing to see in combat.Anime News Network author Amy McNulty, in her review of episode 392 from the anime, writes that Madara has been built up as the ultimate villain for Naruto, and he is living up to that promise.Jason Thompson, also writing for Anime News Network criticized the character calling Madara a "jerk"; but he liked his perfect Sussano'o, which to him looks cooler than the others and is much more powerful.
Madara's origins received a good response. Screen Rant, in their article "15 Things You Didn't Know About Madara", pointed out that the power that Madara sought eventually took over his innocence that was once a part of him. They also praised some of his good qualities including his ideas about gender, money, and power. While describing his love for his brother Izuna, they compared it with Itachi's for Sasuke. According to Screen Rant, Madara is "one of the best evil characters in the series". When first seeing Madara's past, The Fandom Post enjoyed the chaos between the Uchiha and Senju clans. Despite fighting through wars, Madara still showed humanity to the point the reviewer hoped for a spin-off based on the war. In its next review, The Fandom Post enjoyed how his relationship with Hashirama was handled. When Hashirama tried offering him peace it gave the series more of a back story as it focused on the characters' past and the founding of the Hidden Leaf village. Another reviewer from the same site noted that these backstories also helped fans understand the chaos that occurred within the Uchiha clan, which was previously explored in the stories of Sasuke and Itachi. Sasuke needed to resolve whether or not to team up with Madara and destroy the ninja world, leading to his decision to stick with Itachi's ideals instead.
Some critics disliked the handling of the character. In an article from Screen Rant, titled "15 Things Wrong With Naruto We All Choose To Ignore", author Daniel Forster criticized Black Zetsu's betrayal to Madara saying he found Kaguya a poor substitute for Madara who was noted for coming across as a well-developed antagonist. Anime News Network's Amy McNulty, however, thought that this was not that annoying, but she was unsure if it was a smart decision by Kishimoto to have Zetsu stab Madara, who was a genius and who believed Zetsu was "his will incarnate".Comic Book Resources author Renaldo Matadeen criticized the handling of Madara as a villain despite appearing late in the story, and found his characterization weak. While agreeing that Kaguya should not have replaced Madara as the final villain for the Shinobi War, Anime UK News felt that Kaguya was more fleshed out in the anime adaptation making her unique in terms of origins compared with Madara's past. Her descendants had a closer relationship with the protagonists, Naruto and Sasuke.
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Media related to Madara Uchiha at Wikimedia Commons
Naruto: 10 Times Madara Went Too Far
Madara Uchiha is, without a doubt, the most formidable villain in Naruto. He is set up early in the series in hints and clues about who he is and what he’s after, with more information about him being added as the series goes on until, finally, he arrives in the series, a legend resurrected.
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And while it can be expected that villains will do horrible things, Madara, like many Naruto villains, ultimately is trying to do what he thinks is best. When he acknowledges that he perhaps made the wrong choice, he can redeem himself. He has also done some potentially unforgivable things, even in a story of redemption like Naruto.
10 He Drops Meteors On The 4th Division
When Madara first appears on the scene during the Fourth Great Ninja War, everyone is surprised to see him and absolutely dreads having to face him in battle since his reputation definitely precedes him. He essentially takes on an entire division of some of the best-trained ninjas globally, fighting them singlehandedly and decimating them. Just as icing on the cake, since most of them are already dead at this point, he uses his Rinnegan to drop meteors on the group, making sure no one survives.
9 He Uses Clones Against The Kage
When fighting the five strongest ninjas in any of the villages, Madara would likely seem like he was at a disadvantage. In fact, one of the Kage even says as much when they face him since it’s five-on-one. But Madara mocks the entire concept of this, creating clones, furnished with Susanoo, to fight the Kage in his stead. This is solely for his own amusement, as he considers the Kage too weak to bother with, showing both his own arrogance and his lack of respect for any living person.
8 He Acts Against The Senju Without Uchiha Consent
Madara becomes the Uchiha clan leader at a pretty young age, which shows his power and strength, but in some ways, he also regularly shows his own youth as well. Particularly, in his resentment of the Senju clan and his feelings of the Uchiha being disrespected, he acts against them without the consent of the people he claims to lead. Indeed, many of the Uchiha are happy in Konoha as things are, and they have no wish to rock the boat.
7 He Starts The Fourth Great Ninja War
Madara is essentially directly responsible for the beginning of this war, as the very invocation of his name and the possibility that he has been revived is enough to bring the Allied Shinobi Forces together.
RELATED: Naruto: 10 Times Sasuke Went Too Far
The war causes a massive amount of death and destruction, and it leaves Konohagakure in ruins. Madara’s role in this chaos cannot be understated because of his legendary power and his ultimate plans for the Infinite Tsukuyomi. All of the following disasters are ultimately on his shoulders.
6 He Becomes The Jinchuriki Of The Ten-Tails
In one of the most truly destructive choices of the Naruto series's entirety, Madara chooses to become the jinchuriki of the Ten-Tails, which he wants to use to complete the activation of the Infinite Tsukuyomi. But what happens instead is that everyone trapped in the Infinite Tsukuyomi has their power used by Black Zetsu to revive Kaguya, leading to even more death and destruction. While Madara didn’t foresee this outcome, he is ultimately responsible for it.
5 He Didn’t Really Care About The Fate Of The Uchiha
Even though the entirety of Madara’s plan is for the sake of the Uchiha so that everyone can live in peace and there will be no violence between them and others, he doesn’t actually care that activating the Infinite Tsukuyomi won’t actually help them. Everyone in the Uchiha clan is dead, except for Sasuke, and the Eye of the Moon Plan certainly isn’t going to bring them back. But Madara is so far removed from his own reality and goals at this point that he doesn’t really care.
4 He Fights Hashirama
Hashirama Senju reaches out time and again to Madara to broach peace between their clans and create a united Konohagakure. Even though they have been friends for a long time, even though the Senju and Uchiha clans are enemies, Madara rejects these attempts. He ultimately ends up fighting Hashirama for control of the Nine-Tails and the village. It’s one of his earliest betrayals and a sign of the path he plans to walk.
3 He Orchestrates Rin’s Death
There’s always a point when people with good ideas or good intentions turn the corner into doing bad things in the name of their good intentions, and it’s at that point that they become villains.
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In Madara’s case, one of the first horrible things he does is orchestrate Rin’s death so that he can convince Obito to join him in pulling off his Eye of the Moon Plan. Manipulating someone into joining your side and lying to them about it are not morally righteous people's actions.
2 He Nearly Kills Sasuke
Sasuke is so vital to the story that it seems impossible for him to die. And in fact, that ends up being the case since Madara doesn’t actually succeed in killing him, since Karin can heal him after he’s impaled. But the fact that Madara claims to be acting in the name of the Uchiha clan and, indeed, has committed countless crimes and atrocities in the name of their protection makes him seem like a hypocrite for attempting to kill the last living Uchiha.
1 He Activates The Infinite Tsukuyomi
It’s incredibly unusual for a villain in any comic to actually succeed in their goals at the end of the story. But Madara does manage to do it. His Infinite Tsukuyomi plans are that everyone will live in a dream-like world where there is no war or death. It sounds nice, but it also removes everyone’s free will, forcing them to essentially live in a daydream where they cannot think or choose anything for themselves. The peace inherent in this is not worth the price.
NEXT: Naruto: The 10 Strongest Supportive-Jutsu Users, Ranked
NextTop 15 Most Powerful Eye Abilities In AnimeAbout The Author
Liz Adler is a writer and editor based in San Diego, CA. She holds an MFA from San Diego State University and a Bachelor's of Arts from Illinois State University. Her work has been featured at Loser City, HelloGiggles, and Women Write About Comics among others. In her free time, you can find her eating hummus, riding the Haunted Mansion, or being suffocated by her cats, Moo and Mai Tai.
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